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Research Interests:
Family-based genetic association and linkage disequilibrium methods, Bayesian methods in genetic analysis, genetic epidemiology, population structure, likelihood-based inference.
Dr. Varghese George joined the Georgia Health Sciences University in 2005 as Professor and Chair of the Department of Biostatistics. Dr. George has a well-established track record of methodological and collaborative research in Biostatistics, Statistical Genetics and Genetic Epidemiology, which started with his doctorate in Statistics from the University of Missouri-Columbia followed by his post-doctoral fellowship in Statistical Genetics at the Louisiana State University Medical Center in New Orleans under Professor Robert Elston. He continued his career as faculty in the Department of Biometry and Genetics at LSUMC, in the Division of Biostatistics at the Medical College of Wisconsin (MCW), and in the Department of Biostatistics at the University of Alabama at Birmingham (UAB). His primary methodological focus at present is on family-based association and linkage disequilibrium methods, population structure and Bayesian methods in genetic analysis. He is the recipient of several NIH-funded grants as Principal Investigator or Co-investigator. Dr. George has extensive experience in the academic world as an administrative leader, a scientist, a mentor, and an educator. During his tenure at UAB and MCW, he was the Director of Graduate Programs in Biostatistics at both places. Also, while at UAB, Dr. George served as the Director of a NIAMS-funded Annual Short course in Statistical Genetics, as the Co-Director of a NHLBI-funded post-doctoral training program in Statistical Genetics and as the Co-Director of a NIDDK-funded Annual Short Course in Statistical Genetics.
He is a fellow of the American statistical Association, and an elected member of the International Statistical Institute.
Teaching Areas: Graduate teachings in Biostatistics include Probability, Statistical Inference, Statistical Models and Methods, Nonparametric Statistics, Clinical Trials, Likelihood Principle, Applied Regression, Longitudinal Data Analysis, Statistical Genetics, Bayesian Inference, and Advanced Theory of Inference. Other teachings include Biostatistics for Medical Students and MS students in other Health Sciences areas.
Selected Publications:
George V, Elston RC (1987): "Testing the association between polymorphic markers and quantitative traits in pedigrees", Genetic Epidemiology, 4:193.
George V, Elston RC (1988): "Generalized modulus power transformations", Communications in Statistics - Theory and Methods 17:2933.
Elston RC, George V (1989): "Age of onset, age at examination and other covariates in the analysis of family data", Genetic Epidemiology, 6:217.
Johnson WD, George V (1991): "Effect of regression to the mean in the presence of within-subject variability", Statistics in Medicine 10:1295.
George V, Elston RC (1991): "Ascertainment: An overview of the classical segregation analysis model for independent sibships", Biometrical Journal 33:741.
Elston RC, George V, Severtson F (1992): "The Elston-Stewart algorithm for continuous genotypes and environmental factors", Human Heredity 42:16.
George V, Johnson WD (1992): "Effect of regression to the mean in multivariate distributions", Communications in Statistics - Theory and Methods 21:333.
Johnson WD, George V, Shahane A, Fuchs GJ (1992): Fitting growth curve models to longitudinal data with missing observations, Human Biology 64:243.
George V, Elston RC (1993): Confidence limits based on the first occurrence of an event, Statistics in Medicine 12:685.
Heinrich SD, Gallagher D, Warrier R, Phelan K, George V (1994): The prognostic significance of the skeletal manifestations of acute lymphoblastic leukemia of childhood, Journal of Pediatric Orthopedics 14:105.
Nick TG, George V, Elston RC, Wilson AF (1995): Statistical validity for testing associations between genetic markers and quantitative traits in family data, Genetic Epidemiology, 12:145.
Shahane A, George V, Johnson WD (1995): Effect of bivariate regression toward the mean in uncontrolled clinical trials, Communications in Statistics - Theory and Methods 24:2165.
George V, Johnson WD, Shahane A, Nick TG (1997): Testing for treatment effect in the presence of regression toward the mean, Biometrics 53:101.
George V, Tiwari HK, Zhu X, Elston RC (1999): A test of transmission/disequilibrium for quantitative traits in pedigree data, by multiple regression, American Journal of Human Genetics 65: 236.
George V, Tiwari HK, Shu Y, Zhu X, Elston RC (2000): Linkage and association analyses of alcoholism using a regression-based Transmission/disequilibrium test, Genetic Epidemiology 17:S151.
Kotchen TA, Kotchen JM, Grim CE, George V, Kaldunski ML, Cowley AW, Hamet P, Chelius TH (2000): Genetic determinants of hypertension: Identification of candidate phenotypes, Hypertension 36:7.
George V, Laud P (2002): A Bayesian approach to transmission/disequilibrium test for binary traits, Genetic Epidemiology 22:41.
Hajjar IM, George V, Sasse EA, Kochar MS (2002): A randomized double-blind controlled trial of vitamin C in the management of mild hypertension and lipids. American Journal of Therapeutics 9:289.
Yi N, George V, Allison DB (2003): Stochastic Search Variable Selection for Identifying Multiple Quantitative Trait Loci, Genetics 164:1129.
Page GP, George V, Go RC, Page PZ, Allison DB (2003): Are we there yet? Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits, Am J Human Genetics 73: 711.
Yi N, Xu S, George V, Allison DB (2004): Mapping Multiple Quantitative Trait Loci for Ordinal Traits, Behavior Genetics 34: 3.
St-Pierre DH, George V, Rabase-Lhoret R, Poehlman ET (2004): "Genetic variation in response to overfeeding and underfeeding in humans", Nutrition 20: 145
Tiwari HK, Holt J, George V, Beasley TM, Amos CI, Allison DB (2005): "New joint covariance and marginal based tests for association and linkage for quantitative traits for random and non-random sampling", Genetic Epidemiology 28:48.
Zhang K, Wiener H, Beasley TM, George V, Amos CI, Allison DB (2006): "An empirical Bayes method for updating inferences in analysis of QTL using information from related genome scans", Genetics 173: 2283.
Tan Y-D, Fonage M, George V, Xu H (2007): Parent-child pair design for detecting gene-environment interactions in complex diseases. Human Genetics 121:745.
Xu H, George V (2007): A New Transmission Test for Affected Sibships. BMC Genetics, S32.
Dodani S, Kaur R, Reddy S, Reed GL, Navab M, George V (2008): Can dysfunctional HDL explain high coronary artery disease risk in South Asians? International Journal of Cardiology 129:125.
Dodani S, Dong, Y, Zhu H, George V (2008): Can novel Apo A-I polymorphisms be responsible for low HDL in south Asian immigrants? Indian Journal of Human Genetics 14:9.
Xu H, Sarkar B, George V (2009): A new measure of population structure using multiple SNPs and its relationship with FST. BMC Research Notes 2:21.
Xu H, George V (2009): Assessment of population structure and its effects on genome-wide association studies. Communications in Statistics- Theory and Methods 38:2843-2855.
Fernandex-Egea E, Bernardo M, Heaphy CM, Griffith JK, Donner T, Parellada E, Esmatjes E, Conget I, George V, Stoppler H, Kirkpatrick B (2009): Telomore length, Pulse Pressure and glucose mechanism in Schizophrenia. Schizophrenia Bulletin 35:437.
Mukhopadhyay S, George V, Xu H (2010): Variable selection method for quantitative trait analysis based on parallel genetic algorithm. Annals of Human Genetics 74:88-96.
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Full CV